EUROPEAN MARKETS FOR TRANSCATHETER CARDIOVASCULAR THERAPY

362 Pages | 114 Exhibits | 2001 Analysis | Forecasts Through 2005

OVERVIEW:
Despite scientific advancement in the understanding and management of cardiovascular disease, it remains the leading health problem in the European countries covered by this report: the Benelux nations of Belgium, The Netherlands, and Luxembourg; France; Germany; Italy; Spain; and the United Kingdom.

Currently, more than 75 million people in these countries (more than 27% of the adult population) exhibit one or more types of cardiovascular disease. At the same time, the national incidence and prevalence of cardiovascular disease differs considerably from country to country, reflecting asymmetries in dietary habits, lifestyles, relative sophistication of national healthcare, and societal ecology.

In the year 2000, the European transcatheter cardiovascular therapy products market totaled approximately $829 million, and is expected to increase throughout the forecast period covered by this report. This report published by Medtech Insight presents a detailed overview of cardiovascular disease and an analysis of technologies, products, current and forecast markets, competitors, and opportunities in the transcatheter cardiovascular therapy market.

TABLE OF CONTENTS:

EXECUTIVE SUMMARY

     i. Market Overview

     ii. Diagnostic Transcatheter Procedures and Products

     iii. Therapeutic Transcatheter Procedures and Products

     iv. Other Transcatheter Products

     v. National Markets

     vi. Companies

 

1. BACKGROUND ON EUROPEAN MARKETS

     1.1 Overview of European Healthcare

          1.1.1 Healthcare Spending and Reform

          1.1.2 Healthcare Facilities and Manpower

          1.1.3 Reimbursement

          1.1.4 Impact of the European Union

                  1.1.4.1 Medical Device Directive

     1.2 National Profiles

          1.2.1 Belgium

          1.2.2 The Netherlands

          1.2.3 Luxembourg

          1.2.4 France

          1.2.5 Germany

          1.2.6 Italy

          1.2.7 Spain

          1.2.8 United Kingdom

 

2. OVERVIEW OF CARDIOVASCULAR DISEASE IN EUROPE

     2.1 Types

     2.2 Cardiovascular Diseases Requiring Therapeutic Intervention

          2.2.1 Arrhythmia Disorders

                  2.2.1.1 Ventricular Tachycardia

                  2.2.1.2 Supraventricular Tachycardia

                  2.2.1.3 Atrial Fibrillation

                  2.2.1.4 Ventricular Fibrillation

          2.2.2 Coronary Artery Disease

                  2.2.2.1 Angina Pectoris

                  2.2.2.2 Aortic Aneurysm

                  2.2.2.3 Atherosclerosis

                  2.2.2.4 Ischemic Heart Disease

                  2.2.2.5 Myocardial Infarction

          2.2.3 Valve Disorders

                  2.2.3.1 Acquired Valve Disorders

                  2.2.3.2 Congenital Heart Defects

                  2.2.3.3 Rheumatic Heart Disease

     2.3 Cardiovascular Disease Treatment Facilities

     2.4 Cardiovascular Disease Specialists

 

3. TRANSCATHETER INTRACORONARY DIAGNOSTIC DEVICES MARKET

     3.1 Coronary Angiography

          3.1.1 Technique

          3.1.2 Indications

          3.1.3 Procedures

          3.1.4 Products

                  3.1.4.1 Angiography Catheters

                  3.1.4.2 Guidewires

                  3.1.4.3 Sheaths

                  3.1.4.4 Product Suppliers

          3.1.5 Market Analysis

     3.2 Intracoronary Angioscopy

          3.2.1 Technique

          3.2.2 Procedures

          3.2.3 Products

     3.3 Intravascular Ultrasound

          3.3.1 Technique

          3.3.2 Procedures

          3.3.3 Products

          3.3.4 Market Analysis

     3.4 Electrophysiology Studies

          3.4.1 Technique

          3.4.2 Procedures

          3.4.3 Products

          3.4.4 Market Analysis

 

4. PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY

     4.1 Technique

     4.2 Clinical Use and Efficacy

          4.2.1 Complications

          4.2.2 Outcomes versus Competitive Techniques

          4.2.3 Nonfemoral Access

          4.2.4 Expanding Applications

                  4.2.4.1 Primary Angioplasty for Acute Myocardial Infarction

     4.3 Restenosis

          4.3.1 Pathology

                  4.3.1.1 Patient Factors

                  4.3.1.2 Primary Versus Instent Restenosis

          4.3.2 Antirestenosis Approaches

                  4.3.2.1 Drug Therapy

                             4.3.2.1.1 Localized Drug Delivery

                                           4.3.2.1.1.1 Angiogene

                                           4.3.2.1.1.2 InterVentional Technologies

                                                            /Boston Scientific

                  4.3.2.2 Endovascular Brachytherapy

                             4.3.2.2.1 Sources

                             4.3.2.2.2 Potential Risks

                             4.3.2.2.3 Delivery Methods

                             4.3.2.2.4 Source Positioning

                             4.3.2.2.5 Product Development Programs

                                           4.3.2.2.5.1 Boston Scientific

                                           4.3.2.2.5.2 Cordis/Johnson & Johnson

                                           4.3.2.2.5.3 Guidant

                                           4.3.2.2.5.4 Novoste

                                           4.3.2.2.5.5 Radiance Medical Systems

                             4.3.2.2.6 Conclusions and Trends

                  4.3.2.3 Gene Therapy

                  4.3.2.4 Stenting

                  4.3.2.5 Other Energy Sources

                             4.3.2.5.1 Cryotherapy

                             4.3.2.5.2 Intravascular Sonotherapy

                             4.3.2.5.3 Photodynamic Therapy

                             4.3.2.5.4 X-Ray

     4.4 Procedure Volumes

     4.5 Products and Suppliers

          4.5.1 Balloon Catheters

          4.5.2 Guiding Catheters

          4.5.3 Guidewires

          4.5.4 Sheaths

          4.5.5 Other Accessories

     4.6 Market Analysis

          4.6.1 Products

          4.6.2 Antirestenosis Catheters

 

5. CORONARY STENTS

     5.1 Clinical Use

          5.1.1 Technique

          5.1.2 Anticoagulation Regimen

          5.1.3 Optimization of Stent Placement

                  5.1.3.1 Use of Ancillary Imaging

                  5.1.3.2 Improved Delivery Technologies

     5.2 Indications

          5.2.1 Stenting versus Percutaneous Transluminal Coronary

                  Angioplasty

          5.2.2 Stenting Versus Coronary Artery Bypass Grafting

          5.2.3 Stenting in Acute Myocardial Infarction

          5.2.4 European Attitudes Regarding Coronary Stenting

     5.3 Procedure Volumes

     5.4 Coronary Stent Products

          5.4.1 Competitive Factors

          5.4.2 Product Trends

                  5.4.2.1 Antithrombogenic Coatings

                  5.4.2.2 Antirestenosis Coatings

                             5.4.2.2.1 Radioactive Stents

                             5.4.2.2.2 Drug-Coated Stents

     5.5 Market Analysis

 

6. CORONARY ATHERECTOMY AND LASER ANGIOPLASTY

     6.1 Coronary Atherectomy

          6.1.1 Technique

          6.1.2 Approaches and Products

                  6.1.2.1 Directional Coronary Atherectomy

                  6.1.2.2 Rotational Coronary Atherectomy

          6.1.3 Clinical Efficacy

          6.1.4 Debulking Applications

                  6.1.4.1 Debulking Prior to Stenting

                  6.1.4.2 Instent Restenosis

                  6.1.4.3 Peripheral Stenosis and Arteriovascular Access

                            Grafts

     6.2 Laser Angioplasty

          6.2.1 Technique

          6.2.2 Applications

                  6.2.2.1 Instent Restenosis

                  6.2.2.2 Lead Wire Removal

                  6.2.2.3 Peripheral Vascular Disease

                  6.2.2.4 Refractory Total Occlusions

          6.2.3 Products

     6.3 Procedure Volumes

     6.4 Market Analysis

     6.5 Supplier Shares

 

7. CATHETER-BASED ARRHYTHMIA MANAGEMENT

     7.1 Clinical Background

     7.2 Transcatheter Ablation Technique

          7.2.1 Advantages

          7.2.2 Approaches

     7.3 Procedure Volumes

     7.4 Products

     7.5 Market Analysis

 

8. PERCUTANEOUS TRANSMYOCARDIAL REVASCULARIZATION

     8.1 Clinical Background

     8.2 Technique

     8.3 Clinical Trials

     8.4 Mechanisms of Improvement

     8.5 Technique and Design Issues

     8.6 Procedure Volumes

     8.7 Products

          8.7.1 AngioTrax

          8.7.2 Boston Scientific

          8.7.3 Cardiodyne/Trimedyne

          8.7.4 CardioGenesis

                  8.7.4.1 SlimFlex

                  8.7.4.2 Axcis

                  8.7.4.3 New Developments

          8.7.5 Biosense Webster/Johnson & Johnson

          8.7.6 PLC Medical Systems

          8.7.7 Radius Medical Technologies

     8.8 Market Analysis

 

9. OTHER TRANSCATHETER INTERVENTIONS AND DEVICES

     9.1 Arterial Access Closure Devices

          9.1.1 Products

                  9.1.1.1 Catheter-Based

                  9.1.1.2 Collagen Plugs

                             9.1.1.2.1 Datascope

                             9.1.1.2.2 DAIG/St. Jude Medical

                  9.1.1.3 Pressure Wedge Systems

                  9.1.1.4 Occluding Balloon Systems

          9.1.2 Market Analysis

     9.2 Transcatheter Defect Repair and Valvuloplasty

          9.2.1 Percutaneous Balloon Valvuloplasty

                  9.2.1.1 Procedure Description

                  9.2.1.2 Products

                             9.2.1.2.1 Boston Scientific

                             9.2.1.2.2 Toray

                             9.2.1.2.3 University Technologies International

                  9.2.1.3 Procedures

                  9.2.1.4 Market Analysis

          9.2.2 Percutaneous Closure of Heart and Valve Defects

                  9.2.2.1 Patent Ductus Arteriosus

                  9.2.2.2 Other Defects

                             9.2.2.2.1 AGA Medical

                             9.2.2.2.2 Custom Medical Devices

                             9.2.2.2.3 W.L. Gore & Associates

                             9.2.2.2.4 Microvena

                             9.2.2.2.5 NMT Medical

                             9.2.2.2.6 Osypka

                  9.2.2.3 Procedures

                  9.2.2.4 Market Analysis

     9.3 Transcatheter Thrombectomy and Thrombolysis

          9.3.1 Coronary Applications and Efficacy

          9.3.2 Products and Technology

                  9.3.2.1 Mechanical Devices

                             9.3.2.1.1 Angiosonics

                             9.3.2.1.2 Arrow International

                             9.3.2.1.3 Boston Scientific

                             9.3.2.1.4 Cordis/Johnson & Johnson

                             9.3.2.1.5 EndiCOR Medical

                             9.3.2.1.6 Micro Therapeutics

                             9.3.2.1.7 Microvena

                             9.3.2.1.8 Possis Medical

                             9.3.2.1.9 Straub Medical

                  9.3.2.2 Drug Delivery Devices

                             9.3.2.2.1 AngioDynamics

                             9.3.2.2.2 Boston Scientific

                             9.3.2.2.3 Cook Group

                             9.3.2.2.4 Merit Medical Systems

                             9.3.2.2.5 Micro Therapeutics

          9.3.3 Procedures

          9.3.4 Market Analysis

     9.4 Embolic Protection Devices

          9.4.1 Applications

                  9.4.1.1 Saphenous Vein Graft Applications

                  9.4.1.2 Carotid Applications

                  9.4.1.3 Other Applications

          9.4.2 Types of Devices

                  9.4.2.1 Distal Filter Devices

                  9.4.2.2 Distal Balloon Occlusion Devices

                  9.4.2.3 Proximal Balloon Occlusion Devices

          9.4.3 Market Analysis

 

10. COMPANY PROFILES

10.1  Arrow International, Inc.

10.2  Biocompatibles International PLC

10.3  Biotronik GmbH & Co.

10.4  Boston Scientific Corporation

10.5  C.R. Bard, Inc.

10.6  Cardiac Pathways Corporation

10.7  Cardima, Inc.

10.8  CardioGenesis Corporation

10.9  Cook Group, Inc.

10.10 Datascope Corporation

10.11 Guidant Corporation

10.12 Johnson & Johnson

10.13 JOMED NV

10.14 Medtronic, Inc.

10.15 Novoste Corporation

10.16 Spectranetics Corporation

10.17 St. Jude Medical, Inc.

10.18 VascoMed GmbH

 

COMPANY LISTING

LIST OF EXHIBITS

 

Exhibit ES-1:  Coronary Transcatheter Products, Market Forecast, 1999-2005

Exhibit ES-2:  Diagnostic Coronary Transcatheter Products, Market Forecast, 1999-2005 

Exhibit ES-3:  Percutaneous Transluminal Coronary Angioplasty Products and Coronary Stents, Market Forecast, 1999-2005 

Exhibit ES-4:  Arterial Access Closure Devices and Embolic Protection Devices, Market Forecast, 1999-2005 

Exhibit ES-5:  Coronary Transcatheter Products, Market Forecast, by Country, 1999-2005 

Exhibit ES-6:  2000, Coronary Transcatheter Products Market, Share by Supplier

 

Exhibit 1-1:    1999, National Healthcare Expenditures, by Country 

Exhibit 1-2:    1999, Physician and Hospital Data, by Country 

Exhibit 1-3:    European Union Classification System for Medical Devices 

 

Exhibit 2-1:    Overview of Cardiovascular Disease, by Type 

Exhibit 2-2:    1998, Arrhythmia Disorders, Incidence and Prevalence, by Country 

Exhibit 2-3:    1998, Aortic Aneurysm, Incidence and Prevalence, by Country 

Exhibit 2-4:    1998, Ischemic Heart Disease, Prevalence and Mortality, by Country 

Exhibit 2-5:    1998, Acute Myocardial Infarction, Incidence and Mortality, by Country 

Exhibit 2-6:    1998, Valve Disorders, Incidence, by Country 

Exhibit 2-7:    1999, Cardiovascular Disease Treatment Facilities, by Country 

Exhibit 2-8:    2000, National Societies Affiliated with the European Society of Cardiology 

 

Exhibit 3-1:    Indications for Coronary Angiography 

Exhibit 3-2:    2000, Cardiac Catheterization Laboratories and Coronary Angiography Procedures, by Country 

Exhibit 3-3:    Coronary Angiography, Procedure Volumes Forecast, by Country, 1999-2005 

Exhibit 3-4:    2000, Coronary Angiography, Devices per Procedure 

Exhibit 3-5:    Diagnostic Coronary Angiography Products, Market Forecast, 1999-2005 

Exhibit 3-6:    Diagnostic Coronary Angiography Products, Market Forecast, by Country, 1999-2005 

Exhibit 3-7:    2000, Coronary Angiography Products Market, Share by Supplier 

Exhibit 3-8:    Selected Transcatheter Intracoronary Diagnostic Techniques 

Exhibit 3-9:    Coronary Intravascular Ultrasound, Procedure Volumes Forecast, 1999-2005 

Exhibit 3-10:  Coronary Intravascular Ultrasound, Procedure Volumes Forecast, by Country, 1999-2005 

Exhibit 3-11:  2001, Selected Intravascular Ultrasound Catheters Available in Europe 

Exhibit 3-12:  Coronary Intravascular Ultrasound Catheters, Market Forecast, 1999-2005 

Exhibit 3-13:  Coronary Intravascular Ultrasound Catheters, Market Forecast, by Country, 1999-2005 

Exhibit 3-14:  2000, Coronary Intravascular Ultrasound Catheters, Share by Supplier 

Exhibit 3-15:  Diagnostic Electrophysiology Studies, Procedure Volumes Forecast, 1999-2005 

Exhibit 3-16:  Conventional Electrophysiology Studies, Procedure Volumes Forecast, by Country, 1999-2005 

Exhibit 3-17:  Advanced Electrophysiology Studies, Procedure Volumes Forecast, by Country, 1999-2005 

Exhibit 3-18:  2001, Selected Diagnostic Electrophysiology Catheters Available in Europe 

Exhibit 3-19:  Diagnostic Electrophysiology Catheters, Market Forecast, 1999-2005 

Exhibit 3-20:  Conventional Diagnostic Electrophysiology Catheters, Market Forecast, 1999-2005 

Exhibit 3-21:  Advanced Diagnostic Electrophysiology Catheters, Market Forecast, 1999-2005 

Exhibit 3-22:  2000, Conventional Diagnostic Electrophysiology Catheters, Share by Supplier 

Exhibit 3-23:  2000, Advanced Diagnostic Electrophysiology Catheters, Share by Supplier 

 

Exhibit 4-1:    Impact of Age on Angioplasty Results 

Exhibit 4-2:    Comparison of Percutaneous Transluminal Coronary Angioplasty and New Approaches to Coronary Intervention 

Exhibit 4-3:    Six-Month Results of Stent Versus Primary Angioplasty in Myocardial Infarction Trial 

Exhibit 4-4:    Mechanisms of Restenosis 

Exhibit 4-5:    Current and Emerging Antirestenosis Approaches 

Exhibit 4-6:    Pharmaceutical Agents Tested without Success for Restenosis Prevention 

Exhibit 4-7:    2001, Selected Drugs Under Investigation for Restenosis Prevention 

Exhibit 4-8:    Overview of Localized Drug Delivery Approaches for Restenosis Prevention 

Exhibit 4-9:    Characteristics of Beta- versus Gamma-Emitting Radioisotopes 

Exhibit 4-10:  Comparison of Endovascular Brachytherapy Delivery Methods 

Exhibit 4-11:  2001, Selected Endovascular Brachytherapy Programs 

Exhibit 4-12:  Overview of Restenosis Treatments Using Alternative Energy Sources 

Exhibit 4-13:  Percutaneous Transluminal Coronary Angioplasty, Procedure Volumes Forecast, 1999-2005 

Exhibit 4-14:  Percutaneous Transluminal Coronary Angioplasty, Procedure Volumes Forecast, by Country, 1999-2005 

Exhibit 4-15:  2000, Percutaneous Transluminal Coronary Angioplasty, Devices per Procedure 

Exhibit 4-16:  Types of Percutaneous Transluminal Coronary Angioplasty Balloon Catheters 

Exhibit 4-17:  2001, Selected Percutaneous Transluminal Coronary Angioplasty Balloon Catheters Available in Europe 

Exhibit 4-18:  2001, Selected Guiding Catheters Available in Europe 

Exhibit 4-19:  Percutaneous Transluminal Coronary Angioplasty Products, Market Forecast, 1999-2005 

Exhibit 4-20:  Percutaneous Transluminal Coronary Angioplasty Products, Market Forecast, by Country, 1999-2005 

Exhibit 4-21:  2000, Percutaneous Transluminal Coronary Angioplasty Products, Share by Supplier 

 

Exhibit 5-1:    Applications for Ancillary Imaging Techniques in Coronary Stenting 

Exhibit 5-2:    Selected Results of BENESTENT I and STRESS I Trials 

Exhibit 5-3:    European Attitudes Regarding Coronary Stenting 

Exhibit 5-4:    Coronary Stenting, Procedure Volumes Forecast, 1999-2005 

Exhibit 5-5:    Coronary Stenting, Procedure Volumes Forecast, by Country, 1999-2005 

Exhibit 5-6:    2001, Selected Coronary Stents Available in Europe 

Exhibit 5-7:    2001, Selected Antithrombogenic Stents Available in Europe 

Exhibit 5-8:    2001, Selected Radioactive Coronary Stents in Development 

Exhibit 5-9:    2001, Selected Drug-Coated Coronary Stents in Development 

Exhibit 5-10:  Coronary Stents, Market Forecast, 1999-2005 

Exhibit 5-11:  Coronary Stents, Market Forecast, by Country, 1999-2005 

Exhibit 5-12:  Coronary Stents, Unit Volumes Forecast, by Country, 1999-2005 

Exhibit 5-13:  2000, Coronary Stents, Share by Supplier 

 

Exhibit 6-1:    Comparison of Coronary Atherectomy Approaches and Products 

Exhibit 6-2:    Debulking Applications for Coronary Atherectomy 

Exhibit 6-3:    Laser Angioplasty Applications 

Exhibit 6-4:    Spectranetics, Laser Angioplasty Product Overview 

Exhibit 6-5:    Atherectomy and Laser Angioplasty, Procedure Volumes Forecast, 1999-2005 

Exhibit 6-6:    Atherectomy and Laser Angioplasty Consumables, Market Forecast, 1999-2005 

Exhibit 6-7:    2000, Atherectomy and Laser Angioplasty Consumables, Share by Supplier 

 

Exhibit 7-1:    Comparison of Atrial Fibrillation and Ventricular Tachycardia 

Exhibit 7-2:    Standard Radiofrequency Catheter Ablations, Procedure Volumes Forecast, 1999-2005 

Exhibit 7-3:    Standard Radiofrequency Catheter Ablations, Procedure Volumes Forecast, by Country, 1999-2005 

Exhibit 7-4:    Advanced Radiofrequency Catheter Ablations, Procedure Volumes Forecast, 1999-2005 

Exhibit 7-5:    Advanced Radiofrequency Catheter Ablations, Procedure Volumes Forecast, by Country, 1999-2005 

Exhibit 7-6:    Design Criteria for Transcatheter Arrhythmia Management Systems 

Exhibit 7-7:    Current and Emerging Transcatheter Ablation Systems 

Exhibit 7-8:    Ablation Catheters, Market Forecast, 1999-2005 

Exhibit 7-9:    Standard Ablation Catheters, Market Forecast, 1999-2005 

Exhibit 7-10:  Standard Ablation Catheters, Market Forecast, by Country, 1999-2005 

Exhibit 7-11:  Advanced Ablation Catheters, Market Forecast, 1999-2005 

Exhibit 7-12:  Advanced Ablation Catheters, Market Forecast, by Country, 1999-2005 

Exhibit 7-13:  2000, Ablation Catheters, Share by Supplier 

 

Exhibit 8-1:    Standard Angina Pectoris Classification 

Exhibit 8-2:    No-Option Angina Pectoris Patients as Candidates for Transmyocardial Revascularization 

Exhibit 8-3:    Potential Mechanisms of Clinical Improvement Resulting from Transmyocardial Revascularization 

Exhibit 8-4:    Percutaneous Transmyocardial Revascularization, Procedure Volumes Forecast, 1999-2005 

Exhibit 8-5:    2001, Current and Emerging Percutaneous Transmyocardial Revascularization Products 

Exhibit 8-6:    Percutaneous Transmyocardial Revascularization Products, Market Forecast, 1999-2005 

 

Exhibit 9-1:    Selected Femoral Access Closure Devices 

Exhibit 9-2:    Arterial Access Closure Devices, Market Forecast, 1999-2005 

Exhibit 9-3:    Arterial Access Closure Devices, Unit Volumes Forecast, by Country, 1999-2005 

Exhibit 9-4:    Arterial Access Closure Devices, Market Forecast, by Country, 1999-2005 

Exhibit 9-5:    2000, Arterial Access Closure Devices, Share by Supplier 

Exhibit 9-6:    Percutaneous Balloon Valvuloplasty, Procedure Volumes Forecast, 1999-2005 

Exhibit 9-7:    Percutaneous Balloon Valvuloplasty Catheters, Market Forecast, 1999-2005 

Exhibit 9-8:    2000, Percutaneous Balloon Valvuloplasty Catheters, Share by Supplier 

Exhibit 9-9:    Comparison of the Rashkind Occluder and the Gianturco Coil for Percutaneous Closure of Patent Ductus Arteriosus 

Exhibit 9-10:  2001, Selected Transcatheter Cardiac Defect Repair Devices 

Exhibit 9-11:  Transcatheter Cardiac Defect Repairs, Procedure Volumes Forecast, 1999-2005 

Exhibit 9-12:  Transcatheter Cardiac Defect Repair Products, Market Forecast, 1999-2005 

Exhibit 9-13:  2000, Transcatheter Defect Repair Products, Share by Supplier 

Exhibit 9-14:  2001, Current and Emerging Mechanical Thrombectomy Systems 

Exhibit 9-15:  2001, Selected Thrombolytic Drug Delivery Systems 

Exhibit 9-16:  Percutaneous Thrombolysis and Thrombectomy, Procedure Volumes Forecast, 1999-2005 

Exhibit 9-17:  Percutaneous Mechanical Thrombectomy Devices, Market Forecast, 1999-2005 

Exhibit 9-18:  Percutaneous Thrombolysis Catheters, Market Forecast, 1999-2005 

Exhibit 9-19:  2000, Percutaneous Thrombectomy and Thrombolysis Devices Market, Share by Supplier 

Exhibit 9-20:  Comparison of Embolic Protection Device Designs 

Exhibit 9-21:  2001, Selected Distal Filter Embolic Protection Devices 

Exhibit 9-22:  Embolic Protection Devices, Market Forecast, 1999-2005 

Exhibit 9-23:  2000, Embolic Protection Devices Market, Share by Supplier 

 



COMPANIES COVERED:

  1. Arrow International, Inc.
  2. Biocompatibles International PLC
  3. Biotronik GmbH & Co.
  4. Boston Scientific Corporation
  5. C.R. Bard, Inc.
  6. Cardiac Pathways Corporation
  7. Cardima, Inc.
  8. CardioGenesis Corporation
  9. Cook Group, Inc.
  10. Datascope Corporation
  11. Guidant Corporation
  12. Johnson & Johnson
  13. JOMED NV
  14. Medtronic, Inc.
  15. Novoste Corporation
  16. Spectranetics Corporation
  17. St. Jude Medical, Inc.
  18. VascoMed GmbH
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