2015 GLOBAL OPPORTUNITIES IN THE INTERVENTIONAL MANAGEMENT OF SYMPTOMATIC PERIPHERAL ARTERY DISEASE

200 Pages | 66 Exhibits | 2015 Analysis | Forecasts Through 2019

OVERVIEW:
This report focuses on the novel drug-coated balloon and drug-eluting stent technologies that are expected to revolutionize the treatment of limb- and life-threatening symptomatic peripheral artery disease and drive the development of a new, multi-billion dollar market. It also covers revascularization-enabling peripheral atherectomy systems and dedicated refractory CTO crossing devices that are likely to see above-average growth through 2019. Epidemiological, procedure and market data are presented for four market geographies, including the United States, Major Europe (the five largest Western European states), Major Asia-Pacific (encompassing China, India and Japan), and Rest of the World nations. The report projections are based on detailed, clinical and econometric models for the years 2013 through 2019 that are intended to act as a working tool for clients of the report. They provide dynamic models of the covered technologies' utilization patterns and revenue growth within the context of interventional radiology practices in the targeted regions, historic analogies of adoption of similar transcatheter tools and techniques, priorities in local healthcare policies, and availability of funding, among other factors.

TABLE OF CONTENTS:
EXECUTIVE SUMMARY
 
Etiology & Epidemiology of PAD and CLI 
Peripheral Interventional Procedures by Major Type 
Global Market for PAD and CLI Devices by Product Type 
Geographic Markets for PAD and CLI Devices by Product Type 
Major Suppliers of PAD and CLI Devices 

Summary Exhibit 1: Symptomatic PAD Prevalence and CLI Incidence, Global and by Geography 
Summary Exhibit 2: Lower Limb PTAs by Lesion Location & Type, Global and by Geography 
Summary Exhibit 3: Global Market for PAD and CLI Products, 2013-2019 
Summary Exhibit 4: Geographic Markets for PAD and CLI Products, 2013-2019 
Summary Exhibit 5: Global Supplier Shares by Major Product Type, 2014

1.0 ETIOLOGY, EPIDEMIOLOGY & PROCEDURES
 
1.1 Overview of Peripheral Vascular Infrastructure 
1.2 Peripheral Arterial Disease 
	1.2.1 Symptoms 
	1.2.2 Causes 
	1.2.3 Risk Factors 
	1.2.4 Prevalence 
1.3 Critical Limb Ischemia 
	1.3.1 Causes 
	1.3.2 Disease Progression 
	1.3.3 Disease Management and Interventional Therapy 
	1.3.4 Incidence of CLI and Limb Amputation 
1.4 Chronic Total Occlusions 
	1.4.1 Incidence  
	1.4.2 Treatment Regimens 
1.5 PTA Procedures 
	1.5.1 Peripheral Angioplasties by Location 
	1.5.2 Peripheral Angioplasties by Type 

Exhibit 1-1: Major Lower Extremity Arteries 
Exhibit 1-2: Normal versus Atherosclerotic Peripheral Artery 
Exhibit 1-3: Estimated Prevalence of Symptomatic Peripheral Artery Disease by Major Geography, 2013-2019 
Exhibit 1-4: Overview of Peripheral Artery Disease and Critical Limb Ischemia 
Exhibit 1-5: Estimated Incidence of Critical Limb Ischemia and Limb Amputation by Selected Geographies, 2013-2019 
Exhibit 1-6: Development of a Chronic Total Occlusion 
Exhibit 1-7: Peripheral Angioplasty Procedures by Major Geography, 2013-2019 
Exhibit 1-8: Distribution of PTA Procedures by Lesion Location, United States, 2013-2019 
Exhibit 1-9: Distribution of PTA Procedures by Lesion Location, Major Europe, 2013-2019 
Exhibit 1-10: Distribution of PTA Procedures by Lesion Location, Major Asia-Pacific, 2013-2019 
Exhibit 1-11: Distribution of PTA Procedures by Lesion Location, Rest of World, 2013-2019 
Exhibit 1-12: Distribution of Global PTA Procedures by Lesion Location, 2013-2019 
Exhibit 1-13: Distribution of PTA Procedures by Type, United States, 2013-2019 
Exhibit 1-14: Distribution of PTA Procedures by Type, Major Europe, 2013-2019 
Exhibit 1-15: Distribution of PTA Procedures by Type, Major Asia-Pacific, 2013-2019 
Exhibit 1-16: Distribution of PTA Procedures by Type, Rest of World, 2013-2019 
Exhibit 1-17: Distribution of Global PTA Procedures by Type, 2013-2019

2.0 PRODUCTS AND TECHNOLOGIES
 
2.1 Peripheral Drug-Coated Balloons 
	2.1.1 Drug Delivery Methods 
	2.1.2 Balloon Coating Technologies 
	2.1.3 Carrier Excipients 
	2.1.4 Products 
		2.1.4.1 Aachen Resonance 
		2.1.4.2 Bard Peripheral Vascular 
		2.1.4.3 Bayer AG 
		2.1.4.4 Biotronik 
		2.1.4.5 Biosensors International 
		2.1.4.6 Boston Scientific 
		2.1.4.7 Cardionovum 
		2.1.4.8 Cook Medical 
		2.1.4.9 Eurocor 
		2.1.4.10 iVascular 
		2.1.4.11 Medtronic plc 
		2.1.4.12 Spectranetics 
	2.1.5 Second Generation DCB Technologies under Development 
	2.1.6 Clinical Experience with Drug-Coated Balloons. 
2.2 Peripheral Drug-Eluting Stents 
	2.2.1 Anti-Restenosis Drugs 
	2.2.2 Products 
		2.2.2.1 Abbott Vascular 
		2.2.2.2 Alvimedica Medical Technologies 
		2.2.2.3 Boston Scientific 
		2.2.2.4 Cook Medical 
		2.2.2.5 Johnson & Johnson Cordis 
	2.2.3 Clinical Experience with Peripheral DES. 
		2.2.3.1 SIROCCO I and II 
		2.2.3.2 Zilver PTX Trial 
		2.2.3.3 ACHILLES Trial 
		2.2.3.4 DESTINY Trial 
2.3 Peripheral Debulking Technologies 
	2.3.1 Atherectomy Systems 
	2.3.2 Atherotomy Devices 
2.4 Dedicated Refractory CTO Crossing Devices 
	2.4.1 Products 
	2.4.2 Clinical Experience 

Exhibit 2-1: Selected Peripheral Drug-Coated Balloon (DCB) Angioplasty Systems, 2015 
Exhibit 2-2: Performance Data from Clinical Trials of Drug-Coated Balloons versus PTA in Symptomatic Patients with Superficial Femoral Artery (SFA) Occlusiions 
Exhibit 2-3: Performance Data from Clinical Trials of Drug-Coated Balloons versus Peripheral Transluminal Angioplasty in Symptomatic Critical Limb Ischemia Patients with 
Below-the-Knee Arterial Occlusions 
Exhibit 2-4: Selected Peripheral Drug-Eluting Stent Technologies, 2015 
Exhibit 2-5: Performance Data from Clinical Trials of Drug-Coated Stents versus Control in Patients with Symptomatic Critical Limb Ischemia and Super-ficial Femoral 
Artery (SFA) and Below-the-Knee (BTK) Occlusions 
Exhibit 2-6: Overview of Peripheral Debulking Technologies 
Exhibit 2-7: Selected Peripheral Atherectomy Technologies, 2015 
Exhibit 2-8: Selected Atherotomy Technologies, 2015 
Exhibit 2-9: Selected Crossing Support Catheters, 2015 
Exhibit 2-10: Selected Dedicated Refractory CTO Devices, 2015 
Exhibit 2-11: Selected Trials of Dedicated Peripheral Refractory CTO Technologies

3.0 PROCEDURES & MARKETS
 
3.1 Drug-Coated Balloons 
	3.1.1 Procedures and Markets by Geography 
	3.1.2 Competitive Analysis 
3.2 Drug-Eluting Stents 
	3.2.1 Procedures and Markets by Geography 
	3.2.2 Competitive Analysis 
3.3 Atherectomy Devices 
	3.3.1 Procedures and Markets by Geography 
	3.3.2 Competitive Analysis 
3.4 Dedicated Refractory CTO Crossing Devices 
	3.4.1 Procedures and Markets by Geography 
	3.4.2 Competitive Analysis 

Exhibit 3-1: Global Peripheral Drug-Coated Balloon, Procedures and Market, 2013-2019 
Exhibit 3-2: Peripheral Drug-Coated Balloon Angioplasty, United States, Procedures and Market, 2013-2019 
Exhibit 3-3: Peripheral Drug-Coated Balloon Angioplasty, Major Europe, Procedures and Market, 2013-2019 
Exhibit 3-4: Peripheral Drug-Coated Balloon Angioplasty, Major Asia-Pacific, Procedures and Market, 2013-2019 
Exhibit 3-5: Peripheral Drug-Coated Balloon Angioplasty, Rest of World, Procedures and Market, 2013-2019 
Exhibit 3-6: Peripheral Drug-Coated Balloons, Estimated Supplier Shares, 2014 
Exhibit 3-7: Global Peripheral Drug-Eluting Stents, Procedures and Markets, 2013-2019 
Exhibit 3-8: Peripheral Drug-Eluting Stents, United States, Procedures and Markets, 2013-2019 
Exhibit 3-9: Peripheral Drug-Eluting Stents, Major Europe, Procedures and Markets, 2013-2019 
Exhibit 3-10: Peripheral Drug-Eluting Stents, Major Asia-Pacific, Procedures and Markets, 2013-2019 
Exhibit 3-11: Peripheral Drug-Eluting Stents, Rest of World, Procedures and Markets, 2013-2019 
Exhibit 3-12: Peripheral Dug-Eluting Stents, Estimated Supplier Shares, 2014 
Exhibit 3-13: Global Peripheral Atherectomy, Procedures and Markets, 2013-2019 
Exhibit 3-14: Peripheral Atherectomy, United States, Procedures and Markets, 2013-2019 
Exhibit 3-15: Peripheral Atherectomy, Major Europe, Procedures and Markets, 2013-2019 
Exhibit 3-16: Peripheral Atherectomy, Major Asia-Pacific, Procedures and Markets, 2013-2019 
Exhibit 3-17: Peripheral Atherectomy, Rest of World, Procedures and Markets, 2013-2019 
Exhibit 3-18: Peripheral Atherectomy, Estimated Supplier Shares, 2014 
Exhibit 3-19: Global Peripheral Refractory CTO Crossing, Procedures and Markets, 2013-2019 
Exhibit 3-20: Peripheral Refractory CTO Crossing, United States, Procedures and Markets, 2013-2019 
Exhibit 3-21: Peripheral Refractory CTO Crossing, Major Europe, Procedures and Markets, 2013-2019 
Exhibit 3-22: Peripheral Refractory CTO Crossing, Major Asia-Pacific, Procedures and Markets, 2013-2019 
Exhibit 3-23: Peripheral Refractory CTO Crossing, Rest of World, Procedures and Markets, 2013-2019 
Exhibit 3-24: Dedicated Peripheral CTO Crossing Devices, Supplier Shares, 2014

4.0 COMPANY PROFILES
 
4.1 Aachen Resonance 
4.2 Abbott Vascular (Abbott Laboratories) 
4.3 Avinger Medical Technologies 
4.4 Bard Peripheral (C.R. Bard) 
4.5 Bayer HealthCare (Bayer AG) 
4.6 Biosensors International 
4.7 Biotronik 
4.8 Boston Scientific 
4.9 Cardionovum 
4.10 Cardiovascular Systems 
4.11 Cook Medical 
4.12 Cordis (Johnson & Johnson) 
4.13 Eurocor (Opto Circuits) 
4.14 iVascular 
4.15 Medtronic plc 
	4.15.1 Covidien 
	4.15.2 Medtronic 
4.16 Spectranetics 

5.0 MAJOR COUNTRY PROFILES
 
5.1 United States 
5.2 Major Western Europe 
	5.2.1 Overview of European Healthcare 
		5.2.1.1 Healthcare Spending and Reforms 
		5.2.1.2  Healthcare Facilities and Manpower 
		5.2.1.3  Reimbursement 
		5.2.1.4  Impact of the European Union 
	5.2.2 National Healthcare Profiles 
		5.2.2.1 France 
		5.2.2.2 Germany 
		5.2.2.3 Italy 
		5.2.2.4 Spain 
		5.2.2.5 United Kingdom 
5.3 Major Asia-Pacific 
	5.3.1 China 
	5.3.2 India 
	5.3.3 Japan
 
Exhibit 5-1: United States, Selected Health Care Indicators 
Exhibit 5-2: France, Selected Health Care Indicators 
Exhibit 5-3: Germany, Selected Health Care Indicators 
Exhibit 5-4: Italy, Selected Health Care Indicators 
Exhibit 5-5: Spain, Selected Health Care Indicators 
Exhibit 5-6: United Kingdom, Selected Health Care Indicators 
Exhibit 5-7: China, Selected Health Care Indicators 
Exhibit 5-8: India, Selected Health Care Indicators 
Exhibit 5-9: Japan, Selected Health Care Indicators


COMPANIES COVERED:

  1. Aachen Resonance
  2. Abbott Vascular (Abbott Laboratories)
  3. Avinger Medical Technologies
  4. Bard Peripheral (C.R. Bard)
  5. Bayer HealthCare (Bayer AG)
  6. Biosensors International
  7. Biotronik
  8. Boston Scientific
  9. Cardionovum
  10. Cardiovascular Systems
  11. Cook Medical
  12. Cordis (Johnson & Johnson)
  13. Covidien
  14. Eurocor (Opto Circuits)
  15. iVascular
  16. Medtronic plc
  17. Spectranetics
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