During the forecast period covered by this report, the combined U.S. market for osteobiologic and bone growth stimulation products for spine surgery is projected to increase at a compound annual rate of 2.8%, reaching an estimated $2,110.5 million in the year 2016.
This dynamic new report from Medtech Insight includes analyses of the U.S. markets for allograft bone products, electrical osteogenic stimulators, recombinant human bone morphogenetic proteins, and synthetic bone grafts used in spine surgery. Also included in this report are company profiles of the leading competitors in these markets, as well as a clinical overview of the most common spinal diseases/disorders for which spinal fusion is indicated.
EXECUTIVE SUMMARY i. Selected Spinal Disorders a. Degenerative Disc Disease b. Disc Herniation c. Spinal Tumors d. Traumatic Spinal Injuries ii. Allograft Bone Products Used in Spine Surgery a. Market Analysis iii. Synthetic Bone Graft Products Used in Spinal Fusion a. Market Analysis iv. Recombinant Human Bone Morphogenetic Proteins Used in Spinal Fusion a. Market Analysis v. Electrical Osteogenic Stimulators Used in Spinal Fusion a. Market Analysis vi. Combined Market Forecast vii. Methodology Exhibit ES-1: Prevalence of Selected Spinal Disorders, 2011-2016 Exhibit ES-2: Incidence of Selected Spinal Disorders, 2011-2016 Exhibit ES-3: Allograft Bone Products Used in Spine Surgery, Market Forecast, 2011-2016 Exhibit ES-4: Synthetic Bone Graft Substitutes Used in Spinal Fusion, Market Forecast, 2011-2016 Exhibit ES-5: Recombinant Human Bone Morphogenetic Protein Products, Market Forecast, 2011-2016 Exhibit ES-6: Electrical Osteogenic Stimulators Used in Spinal Fusion, Market Forecast, 2011-2016 Exhibit ES-7: Osteobiologic and Bone Growth Stimulation Products for Spine Surgery, Combined Market Forecast, 2011-2016 1. CLINICAL OVERVIEW 1.1 The Human Spine 1.2 Bone Structure and Function 1.2.1 Bone Formation 1.2.2 Cellular Framework 22.214.171.124 Osteoblasts 126.96.36.199 Osteocytes 188.8.131.52 Osteoclasts 1.2.3 The Fracture Healing Process 1.2.4 Factors Affecting Bone Physiology 184.108.40.206 The Effect of Physical Stress on Bone Remodeling 220.127.116.11 Age and Gender 18.104.22.168 Physical Activity 22.214.171.124 Obesity 126.96.36.199 Cigarette Smoking, Alcohol, and Caffeine 188.8.131.52 Nutritional Deficiencies 1.3 Selected Spinal Disorders 1.3.1 Disc Herniation 1.3.2 Degenerative Disc Disease 184.108.40.206 Arthritis 220.127.116.11.1 Osteoarthritis 18.104.22.168.2 Rheumatoid Arthritis 22.214.171.124.3 Ankylosing Spondylitis 126.96.36.199 Osteoporosis 188.8.131.52 Spondylosis 1.3.3 Abnormal Curvature of the Spine 184.108.40.206 Scoliosis 220.127.116.11 Kyphosis and Lordosis 1.3.4 Spondylolisthesis 1.3.5 Stenosis 1.3.6 Spinal Tumors 1.3.7 Traumatic Spinal Injuries 1.3.8 Vertebral Fractures 1.4 Spine Treatment Options 1.4.1 Spinal Decompression 18.104.22.168 Corpectomy 22.214.171.124 Discectomy 126.96.36.199 Facetectomy 188.8.131.52 Foraminotomy/Foraminectomy 184.108.40.206 Laminotomy/Laminectomy 1.4.2 Spinal Fusion 220.127.116.11 Instrumented versus Noninstrumented Spinal Fusion 18.104.22.168.1 Instrumented Spinal Fusion 22.214.171.124.2 Noninstrumented Spinal Fusion 126.96.36.199 Types of Fusion 188.8.131.52.1 Cervical Fusion 184.108.40.206.2 Anterior Cervical Fusion 220.127.116.11.3 Posterior Cervical Fusion 18.104.22.168.4 Interbody Fusion 22.214.171.124.5 Lumbar Fusion 126.96.36.199.5.1 Anterior Lumbar Interbody Fusion 188.8.131.52.5.2 Posterior Lumbar Interbody Fusion 184.108.40.206.5.3 Transforaminal Lumbar Interbody Fusion 220.127.116.11.6 Posterolateral Fusion 18.104.22.168.7 360-Degree Fusion 22.214.171.124.8 Thoracic and Thoracolumbar Fusion 126.96.36.199.9 Percutaneous or Minimally Invasive Fusion 1.4.3 Posterior Dynamic Stabilization 1.5 Market Dynamics 1.5.1 Demographics 1.5.2 Reimbursement 1.5.3 Patient Protection and Affordable Care Act 1.5.4 Federal Oversight of Physician/Corporate Relationships 1.5.5 Procedure Volumes Forecast Exhibit 1-1: The Human Spine Exhibit 1-2: The Structure of Collagen Exhibit 1-3: The Structure of Hydroxyapatite Exhibit 1-4: The Structure of Bone Exhibit 1-5: Bone Density Averages in the General Population Exhibit 1-6: Bone Density Averages in Olympic Athletes in Comparison with the General Population Exhibit 1-7: Number of Overweight and Obese People, 2011 and 2016 Exhibit 1-8: A Herniated Disc Exhibit 1-9: Bone Density in Normal and Osteoporotic Bone Tissue Exhibit 1-10: Prevalence of Selected Spinal Disorders, 2011-2016 Exhibit 1-11: Incidence of Selected Spinal Disorders, 2011-2016 Exhibit 1-12: The Anatomy of a Spinal Segment Exhibit 1-13: Noninstrumented Spinal Fusion Exhibit 1-14: United States Population Growth Trends Exhibit 1-15: Spinal Fusion Diagnosis-Related Groups and Associated Medicare Reimbursement Exhibit 1-16: Spinal Fusion, Procedure Volumes Forecast, 2010-2016 2. ALLOGRAFT BONE PRODUCTS USED IN SPINE SURGERY 2.1 Regulations Governing Allograft Providers 2.2 Processing Allograft Bone 2.2.1 Tissue Recovery 2.2.2 Tissue Processing 2.3 Allograft Forms 2.3.1 Support Structures 2.3.2 Osteoconductive Fillers 2.3.3 Osteoinductive Materials 2.4 Allograft Tissue Providers 2.5 Market Analysis 2.5.1 Allograft Structural Elements 2.5.2 Allograft Fillers 2.5.3 Demineralized Bone Matrix 2.6 Competitive Analysis Exhibit 2-1: 2012, Selected Allograft Bone Products Used in Spine Surgery Exhibit 2-2: 2012, Selected Demineralized Bone Matrix Products Exhibit 2-3: 2011, Comparison of Allograft Sales, by Distribution Channel Exhibit 2-4: Allograft Bone Products Used in Spine Surgery, Market Forecast, 2011-2016 Exhibit 2-5: Allograft Bone Products Used in Spine Surgery, Market Segment Shares, 2011 and 2016 Exhibit 2-6: 2011, Market for Allograft Bone Products Used in Spine Surgery, Share by Supplier 3. SYNTHETIC BONE GRAFT PRODUCTS USED IN SPINAL FUSION 3.1 Products 3.2 Emerging Products 3.3 Market Analysis 3.4 Competitive Analysis Exhibit 3-1: 2012, Selected Synthetic Bone Graft Products Used in Spinal Fusion Exhibit 3-2: Synthetic Bone Graft Substitutes Used in Spinal Fusion, Market Forecast, 2011-2016 Exhibit 3-3: 2011, Market for Synthetic Bone Graft Substitutes Used in Spinal Fusion, Share by Supplier 4. RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEINS USED IN SPINAL FUSION 4.1 Products 4.1.1 Infuse Bone Graft 4.1.2 Osteogenic Protein-1 4.2 Emerging Products 4.3 Market Analysis Exhibit 4-1: Selected Bone Morphogenetic Proteins Exhibit 4-2: 2012, Selected Recombinant Human Bone Morphogenetic Protein Products Exhibit 4-3: Recombinant Human Bone Morphogenetic Protein Products, Market Forecast, 2011-2016 5. ELECTRICAL OSTEOGENIC STIMULATORS USED IN SPINAL FUSION 5.1 Direct Current Electrical Osteogenic Stimulation 5.2 Capacitive Coupling Electrical Osteogenic Stimulation 5.3 Combined Magnetic Field Osteogenic Stimulation 5.4 Pulsed Electromagnetic Field Osteogenic Stimulation 5.5 Reimbursement 5.6 Products 5.7 Market Analysis 5.8 Competitive Analysis Exhibit 5-1: Direct Current Osteogenic Stimulators Exhibit 5-2: Capacitive Coupling Osteogenic Stimulator Exhibit 5-3: Combined Magnetic Field Osteogenic Stimulator Exhibit 5-4: External Pulsed Electromagnetic Field Osteogenic Stimulators Exhibit 5-5: Selected Indications for Electrical Osteogenic Stimulation Used in Spinal Fusion Exhibit 5-6: 2012, Electrical Osteogenic Stimulator Products Used in Spinal Fusion Exhibit 5-7: Electrical Osteogenic Stimulators Used in Spinal Fusion, Market Forecast, 2011-2016 Exhibit 5-8: 2011, Market for Electrical Osteogenic Stimulators Used in Spinal Fusion, Share by Supplier 6. COMPANY PROFILES 6.1 AlloSource, Inc. 6.2 Biomet, Inc. 6.3 Integra LifeSciences Corporation 6.4 LifeNet Health, Inc. 6.5 Medtronic, Inc. 6.6 Musculoskeletal Transplant Foundation 6.7 Orthofix International NV 6.8 Stryker Corporation APPENDIX: COMPANY LISTING