EUROPEAN MARKETS FOR CURRENT AND EMERGING ORTHOPEDIC BIOMATERIALS

429 Pages | 183 Exhibits | 2006 Analysis | Forecasts Through 2010

OVERVIEW:


TABLE OF CONTENTS:
EXECUTIVE SUMMARY

i. European Healthcare Markets

ii. Musculoskeletal System Overview

iii. Orthopedic Tissue Grafts, Placement Volumes and Products Markets

iv. Bone Graft Substitutes, Placement Volumes and Products Markets

v. Bone Growth Factors, Placement Volumes and Products Markets

vi. Arthroscopic Devices, Placement Volumes and Products Markets

1. EUROPEAN HEALTHCARE MARKET OVERVIEW

1.1 The European Union

1.1.1 A Common Currency

1.1.2 Regulatory Policies

1.1.3 Reimbursement

1.1.4 Factors Affecting Healthcare Delivery

1.1.4.1 Aging Population

1.1.4.2 Cost Containment

1.1.4.3 Industry Consolidation

1.1.4.4 Managed Care

1.1.5 Healthcare Spending

1.2 Selected European National Healthcare Profiles

1.2.1 France

1.2.1.1 Healthcare Organization and Reform

1.2.1.2 Hospital Services

1.2.1.3 Medical Device Reimbursement

1.2.2 Germany

1.2.2.1 Healthcare Organization and Reform

1.2.2.2 Hospital Services

1.2.2.3 Medical Device Reimbursement

1.2.3 Italy

1.2.3.1 Healthcare Organization and Reform

1.2.3.2 Hospital Services

1.2.3.3 Medical Device Reimbursement

1.2.4 Spain

1.2.4.1 Healthcare Organization and Reform

1.2.4.2 Hospital Services

1.2.4.3 Medical Device Reimbursement

1.2.5 United Kingdom

1.2.5.1 Healthcare Organization and Reform

1.2.5.2 Hospital Services

1.2.5.3 Medical Device Reimbursement

1.2.6 Rest of Europe

1.2.6.1 Healthcare Organization and Reform

1.2.6.2 Hospital Services

1.2.6.3 Medical Device Reimbursement

Exhibit 1-1: European Union, Medical Devices Risk Classification System

Exhibit 1-2: European Union, Population Statistics Comparison, 1994 and 2004

Exhibit 1-3: France, Selected National Healthcare Statistics

Exhibit 1-4: Germany, Selected National Healthcare Statistics

Exhibit 1-5: Italy, Selected National Healthcare Statistics

Exhibit 1-6: Spain, Selected National Healthcare Statistics

Exhibit 1-7: United Kingdom, Selected National Healthcare Statistics

2. MUSCULOSKELETAL SYSTEM OVERVIEW

2.1 Bone Structure and Function

2.1.1 Cells

2.1.1.1 Osteoblasts

2.1.1.2 Osteocytes

2.1.1.3 Osteoclasts

2.1.2 Tissues

2.1.2.1 Compact Bone

2.1.2.2 Spongy Bone

2.1.2.3 Bone Marrow

2.1.2.4 Endosteum

2.1.2.5 Periosteum

2.1.3 Bone Formation and Resorption

2.1.3.1 In the Fetus

2.1.3.2 In Childhood

2.1.3.3 In Adulthood

2.1.3.4 In Old Age

2.1.3.5 Mechanical Stress and Wolff's Law

2.1.4 Factors Affecting Bone Physiology

2.1.4.1 Age

2.1.4.2 Gender

2.1.4.3 Genetic Disposition

2.1.4.4 Hormonal Activity

2.1.4.5 Physical Activity

2.1.4.6 Cigarette Smoking

2.1.4.7 Alcohol and Caffeine Intake

2.1.4.8 Nutritional Deficiencies

2.1.5 Selected Diseases and Disorders that Affect Bones

2.1.5.1 Fractures

2.1.5.2 Osteoporosis

2.1.5.3 Osteosarcoma

2.1.5.4 Paget's Disease

2.1.5.5 Rickets/Osteomalacia

2.2 Joint Structure and Function

2.2.1 Types of Joints

2.2.1.1 Synarthroses

2.2.1.2 Amphiarthroses

2.2.1.3 Diarthroses

2.2.1.3.1 Ball-and-Socket

2.2.1.3.2 Condyloid

2.2.1.3.3 Hinge

2.2.1.3.4 Gliding

2.2.1.3.5 Pivot

2.2.2 Joint Components

2.2.2.1 Articular Cartilage

2.2.2.2 Bursae

2.2.2.3 Joint Cavity

2.2.2.4 Meniscus

2.2.2.5 Synovial Membrane and Fluid

2.2.2.6 Ligaments and Tendons

2.2.3 Selected Diseases and Disorders that Affect Joints

2.2.3.1 Arthritis

2.2.3.1.1 Osteoarthritis

2.2.3.1.2 Rheumatoid Arthritis

2.2.3.2 Dislocation

2.3.3.3 Ligament and Tendon Injuries

2.3.3.4 Meniscal Injuries

2.3 Management of Bone and Joint Disorders

2.3.1 Fracture Management

2.3.2 Joint Replacement

2.3.3 Arthroscopy

Exhibit 2-1: Illustration of Bone Tissue

Exhibit 2-2: Types of Cartilage

Exhibit 2-3: Classifications of Fractures

3. BIOMATERIALS IN ORTHOPEDIC AND ARTHROSCOPIC SURGERY APPLICATIONS

3.1 Introduction to Biomaterials

3.1.1 Definition of Biomaterials

3.1.2 Biomaterial Sources

3.1.2.1 Biomaterials Derived from Living Tissues

3.1.2.2 Synthetic Biomaterials

3.1.2.2.1 Organic

3.1.2.2.2 Inorganic

3.1.2.3 Hybrid Biomaterials

3.1.3 Biomaterials and Biocompatibility

3.1.3.1 Nonresorbable Biomaterials

3.1.3.2 Resorbable and Soluble Biomaterials

3.1.3.3 Host Tissue Response to Biomaterials

3.1.4 Tissue Engineering and the Use of Biomaterial Scaffolds

3.1.4.1 Scaffolds for Bone Tissue Regeneration/Repair

3.1.4.2 Scaffolds for Cartilage Tissue Regeneration/Repair

3.1.4.3 Scaffolds for Meniscal Tissue Regeneration/Repair

3.1.4.4 Tissue Engineering Techniques and Bone Growth Factors

3.1.4.5 Tissue Engineering Techniques and Gene Therapy

3.2 Reconstructive Materials

3.2.1 Metals

3.2.1.1 Cobalt Alloys

3.2.1.1.1 Structure and Properties

3.2.1.1.2 Tissue Response

3.2.1.1.3 Advantages and Disadvantages

3.2.1.2 Stainless Steel Alloys

3.2.1.2.1 Structure and Properties

3.2.1.2.2 Tissue Response

3.2.1.2.3 Advantages and Disadvantages

3.2.1.3 Titanium Alloys

3.2.1.3.1 Structure and Properties

3.2.1.3.2 Tissue Response

3.2.1.3.3 Advantages and Disadvantages

3.2.2 Ceramics

3.2.2.1 Aluminum Oxides

3.2.2.1.1 Structure and Properties

3.2.2.2 Calcium Phosphates

3.2.2.2.1 Structure and Properties

3.2.2.3 Glass Ceramics

3.2.2.3.1 Structure and Properties

3.2.2.4 Tissue Response to Ceramic Implant/Coating Materials

3.2.2.5 Advantages and Disadvantages of Ceramic Implant/Coating Materials

3.2.3 Polymers

3.2.3.1 Carbon Fiber

3.2.3.1.1 Structure and Properties

3.2.3.2 Silicone Rubber

3.2.3.2.1 Structure and Properties

3.2.3.3 Polyethylene

3.2.3.3.1 Structure and Properties

3.2.3.4 Polytetrafluoroethylene

3.2.3.4.1 Structure and Properties

3.2.3.5 Polyurethanes

3.2.3.5.1 Structure and Properties

3.2.3.6 Ultrahigh Molecular-Weight Polyethylene

3.2.3.6.1 Structure and Properties

3.2.3.7 Tissue Response to Polymer Implants

3.2.3.8 Advantages and Disadvantages

3.2.4 Resorbable Materials

3.2.4.1 Polyglycolic Acid

3.2.4.2 Polylactic Acid

3.2.4.3 Copolymers

Exhibit 3-1: 2006, Selected Synthetic Biomaterials Used in Tissue Engineering and Organ Replacement/Regeneration

Exhibit 3-2: American Society for Testing and Materials D1418 Silicone Rubber Classifications

4. ORTHOPEDIC TISSUE GRAFTS MARKET

4.1 Types of Tissue Grafts

4.1.1 Autografts

4.1.1.1 Advantages and Disadvantages of Use

4.1.2 Allografts

4.1.2.1 Advantages and Disadvantages of Use

4.1.3 Xenografts

4.1.3.1 Advantages and Disadvantages of Use

4.2 Bone Allografts

4.2.1 Mechanisms of Bone Graft Activity

4.2.1.1 Osteoconduction

4.2.1.2 Osteogenesis

4.2.1.3 Osteoinduction

4.2.2 Types of Bone Allografts

4.2.2.1 Large and Intercalary Allografts

4.2.2.1.1 Indications for Use

4.2.2.1.2 Products/Technologies

4.2.2.1.3 Placement Volumes Forecast

4.2.2.1.4 Market Forecast

4.2.2.2 Bone Dowels, Pins, Screws, and Wedges

4.2.2.2.1 Indications for Use

4.2.2.2.2 Products/Technologies

4.2.2.2.3 Placement Volumes Forecast

4.2.2.2.4 Market Forecast

4.2.2.3 Machined Cortical Bone Allografts

4.2.2.3.1 Indications for Use

4.2.2.3.2 Products/Technologies

4.2.2.3.3 Placement Volumes Forecast

4.2.2.3.4 Market Forecast

4.2.2.4 Milled and Blended Bone Allografts

4.2.2.4.1 Indications For Use

4.2.2.4.2 Products/Technologies

4.2.2.4.3 Placement Volumes Forecast

4.2.2.4.4 Market Forecast

4.2.2.5 Osteoarticular Allografts

4.2.2.5.1 Indications for Use

4.2.2.5.2 Products/Technologies

4.2.2.5.3 Placement Volumes Forecast

4.2.2.5.4 Market Forecast

4.3 Tendon and Ligament Allografts

4.3.1 Indications for Use

4.3.2 Products/Technologies

4.3.3 Placement Volumes Forecast

4.3.4 Market Forecast

4.4 Meniscus Allografts

4.4.1 Indications for Use

4.4.2 Products/Technologies

4.4.3 Placement Volumes Forecast

4.4.4 Market Forecast

4.5 Orthopedic Tissue Grafts Market Analysis

4.5.1 Market Forecasts

4.5.1.1 Europe

4.5.1.2 France

4.5.1.3 Germany

4.5.1.4 Italy

4.5.1.5 Spain

4.5.1.6 United Kingdom

4.5.1.7 Rest of Europe

4.5.2 Competitive Analysis

4.5.2.1 Europe

4.5.2.2 France

4.5.2.3 Germany

4.5.2.4 Italy

4.5.2.5 Spain

4.5.2.6 United Kingdom

4.5.2.7 Rest of Europe

Exhibit 4-1: Types of Bone Grafts

Exhibit 4-2: 2006, Base Tissue Bone Allografts Used in Orthopedic Surgical Procedures

Exhibit 4-3: Large and Intercalary Allograft Grafts, Market Forecast, 2004-2010

Exhibit 4-4: 2006, Types of Bioresorbable Fixation Products

Exhibit 4-5: 2006, Selected Bioresorbable Fixation Products

Exhibit 4-6: Bones, Dowels, Pins, Screws, and Wedges Grafts, Market Forecast, 2004-2010

Exhibit 4-7: 2006, Major Indications for Bone Grafts

Exhibit 4-8: 2006, Selected Machined Cortical Allograft Implant Products

Exhibit 4-9: Machined Cortical Bone Allografts, Market Forecast, 2004-2010

Exhibit 4-10: Milled and Blended Bone Allograft Grafts, Market Forecast, 2004-2010

Exhibit 4-11: Osteoarticular Allograft Grafts, Market Forecast, 2004-2010

Exhibit 4-12: 2006, Selected Emerging Polymer-Based Scaffolds for Ligament and Tendon Repair

Exhibit 4-13: Tendon and Ligament Allograft Grafts, Market Forecast, 2004-2010

Exhibit 4-14: 2006, Selected Emerging Meniscal Repair and Replacement Products

Exhibit 4-15: Meniscus Allograft Grafts, Market Forecast, 2004-2010

Exhibit 4-16: Orthopedic Tissue Grafts, European Market Forecast, 2004-2010

Exhibit 4-17: Orthopedic Tissue Grafts, France Market Forecast, 2004-2010

Exhibit 4-18: Orthopedic Tissue Grafts, Germany Market Forecast, 2004-2010

Exhibit 4-19: Orthopedic Tissue Grafts, Italy Market Forecast, 2004-2010

Exhibit 4-20: Orthopedic Tissue Grafts, Spain Market Forecast, 2004-2010

Exhibit 4-21: Orthopedic Tissue Grafts, United Kingdom Market Forecast, 2004-2010

Exhibit 4-22: Orthopedic Tissue Grafts, Rest of Europe Market Forecast, 2004-2010

Exhibit 4-23: 2005, European Market Orthopedic Tissue Grafts Market, Share by Supplier

Exhibit 4-24: 2005, France Orthopedic Tissue Grafts Market, Share by Supplier

Exhibit 4-25: 2005, Germany Orthopedic Tissue Grafts Market, Share by Supplier

Exhibit 4-26: 2005, Italy Orthopedic Tissue Grafts Market, Share by Supplier

Exhibit 4-27: 2005, Spain Orthopedic Tissue Grafts Market, Share by Supplier

Exhibit 4-28: 2005, United Kingdom Orthopedic Tissue Grafts Market, Share by Supplier

Exhibit 4-29: 2005, Rest of Europe

COMPANIES COVERED:

  1. Biomet Europe/Biomet, Inc.
  2. Bioniche Pharma Group LTD
  3. Chiesi Farmaceutici SPA
  4. DePuy Spine, Inc./Johnson & Johnson
  5. FIDIA Group
  6. enzyme Biosurgery Corporation/Genzyme Corporation
  7. Harvest Technologies Corporation
  8. Isotis OrthoBiologics, Inc./IsoTis SA
  9. Linvatec Corporation/ConMED Corporation
  10. Walter Lorenz Surgical, Inc./Biomet, Inc
  11. Medtronic, Inc.
  12. DePuy Mitek, Inc./Johnson & Johnson
  13. Orthovita, Inc.
  14. Osteotech, Inc
  15. Smith & Nephew PLC
  16. Stryker Biotech/Stryker Corporation
  17. Sulzer Innotec AG
  18. Synthes, Inc./Synthes AG
  19. Verigen Transplantation Services LTD/Verigen AG
  20. Wright Medical Technology, Inc./Wright Medical Group
  21. Zimmer Holdings Inc.
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