This dynamic new report from Medtech Insight includes analyses of products, competitors, and opportunities in the U.S. market for biomaterial products for bone healing/regeneration and spinal fusion indications. This market, as covered by the scope of this report, includes bioresorbable fixation devices (pins, screws, tacks, suture anchors, and meniscal repair devices); allografts and bone replacement materials (base tissue, demineralized bone matrix, machined bone allografts, and synthetic bone grafts), and osteobiologics (autologous therapy/platelet concentrate systems, gene therapy, platelet-derived growth factors, recombinant human bone morphogenetic proteins, small molecule therapies, and stem cells). During the forecast period covered by this report, the combined U.S. market for orthopedic biomaterials for bone repair and regeneration is projected to reach an estimated value of $3.5 billion in the year 2017.
This is the first of two reports covering the U.S. market for orthopedic biomaterials. Report #A322, "U.S. Markets for Orthopedic Biomaterials for Viscosupplementation and Cartilage, Ligament/Tendon, and Meniscal Repair and Regeneration" has also published.
EXECUTIVE SUMMARY i. Bioresorbable Fixation Devices ii. Bone Allograft and Synthetic Bone Graft Products iii. Osteobiologics iv. Combined Market Forecast v. Methodology Exhibit ES-1: Types of Bioresorbable Fixation Devices Exhibit ES-2: Bioresorbable Fixation Devices, Market Forecast, 2012-2017 Exhibit ES-3: Bone Allografts and Synthetic Bone Graft Substitutes, Market Forecast, 2012-2017 Exhibit ES-4: 2012, Bone Allografts and Synthetic Bone Graft Substitutes Market, Share by Tissue Type Exhibit ES-5: Recombinant Human Bone Morphogenetic Protein Products, Market Forecast, 2012-2017 Exhibit ES-6: Osteobiologics, Market Forecast, 2012-2017 Exhibit ES-7: 2012, Market Shares of Stem Cell Applications for Bone Healing and Spinal Fusion Exhibit ES-8: Orthopedic Biomaterials for Bone Repair and Regeneration, Combined Market Forecast, 2012-2017 1. MUSCULOSKELETAL SYSTEM OVERVIEW 1.1 Bone Structure and Function 1.1.1 Cellular Framework 188.8.131.52 Osteoblasts 184.108.40.206 Osteocytes 220.127.116.11 Osteoclasts 18.104.22.168 Osteogenesis 1.1.2 Bone Tissue 22.214.171.124 Cancellous and Cortical Bone Tissue 126.96.36.199 Bone Marrow 1.1.3 Bone Anatomy 188.8.131.52 Diaphysis and Epiphysis 184.108.40.206 Endosteum 220.127.116.11 Periosteum 1.1.4 Joint Components 18.104.22.168 Cartilage 22.214.171.124.1 Elastic Cartilage 126.96.36.199.2 Fibrocartilage 188.8.131.52.3 Hyaline Cartilage 184.108.40.206 Bursae 220.127.116.11 Joint Cavity 18.104.22.168 Menisci 22.214.171.124 Synovial Membrane and Fluid 126.96.36.199 Ligaments and Tendons 188.8.131.52 Muscles 1.1.5 Joint Structures 184.108.40.206 Ankle 220.127.116.11 Digits 18.104.22.168 Elbow 22.214.171.124 Hip 126.96.36.199 Knee 188.8.131.52 Shoulder 184.108.40.206 Wrist 1.1.6 Bone Formation and Remodeling 220.127.116.11 In the Fetus 18.104.22.168 In Childhood 22.214.171.124 In Adulthood 126.96.36.199 In Old Age 188.8.131.52 Mechanical Stress and Wolff's Law 1.1.7 Factors Affecting Bone Physiology 184.108.40.206 Age 220.127.116.11 Gender 18.104.22.168 Genetic Disposition 22.214.171.124 Hormonal Activity 126.96.36.199 Physical Activity 188.8.131.52 Cigarette Smoking 184.108.40.206 Alcohol and Caffeine Intake 220.127.116.11 Nutritional Deficiencies 1.2 Joint Structure and Function 1.2.1 Types of Joints 18.104.22.168 Synarthroses 22.214.171.124 Amphiarthroses 126.96.36.199 Diarthroses 188.8.131.52.1 Ball-and-Socket 184.108.40.206.2 Condyloid 220.127.116.11.3 Hinge 18.104.22.168.4 Gliding 22.214.171.124.5 Pivot 1.2.2 Arthritis 126.96.36.199 Osteoarthritis 188.8.131.52 Rheumatoid Arthritis 1.3 Management of Joint Disorders 1.3.1 Joint Replacement 184.108.40.206 Dislocation 220.127.116.11 Ligament and Tendon Injuries 18.104.22.168 Meniscal Injuries Exhibit 1-1: Illustration of Bone Tissue Exhibit 1-2: Types of Cartilage Exhibit 1-3: Stages of Bone Remodeling 2. BIORESORBABLE FIXATION DEVICES 2.1 Materials 2.2 Products 2.2.1 Bioresorbable Pins 2.2.2 Bioresorbable Screws, Nails, and Tacks 2.2.3 Bioresorbable Interference Screws 2.2.4 Bioresorbable Suture Anchors 2.2.5 Bioresorbable Meniscal Repair Devices 2.3 Market Analysis 2.3.1 Potential Market for Bioresorbable Fixation Devices 22.214.171.124 Meniscal Repair 126.96.36.199 Cruciate Ligament Fixation 188.8.131.52 Shoulder Reconstruction 184.108.40.206 Small Joint/Bone Fragment Fixation 2.4 Competitive Analysis Exhibit 2-1: Advantages of Bioresorbable Fixation Devices Exhibit 2-2: Factors Affecting the Properties of Bioresorbable Polymers Exhibit 2-3: Types of Bioresorbable Fixation Devices Exhibit 2-4: 2013, Selected Bioresorbable Pins Exhibit 2-5: 2013, Selected Bioresorbable Nails, Screws, and Tacks Exhibit 2-6: 2013, Selected Bioresorbable Interference Screws Exhibit 2-7: 2013, Selected Bioresorbable Suture Anchors Exhibit 2-8: 2013, Selected Bioresorbable Meniscal Repair Devices Exhibit 2-9: 2012, Bioresorbable Fixation Devices Market, By Procedure Type Exhibit 2-10: Bioresorbable Fixation Devices, Market Forecast, 2012-2017 Exhibit 2-11: 2012, Bioresorbable Fixation Devices Market, Share by Supplier 3. BONE ALLOGRAFT AND SYNTHETIC BONE GRAFT PRODUCTS 3.1 Bone Graft Materials 3.1.1 Autograft 3.1.2 Allograft 220.127.116.11 Regulations Governing Allograft Providers 18.104.22.168.1 National Organ Transplant Act 22.214.171.124.2 United States Food and Drug Administration Requirements 126.96.36.199 Donor Screening 188.8.131.52 Recovering Tissue 184.108.40.206 Processing Tissue 220.127.116.11 Tissue Banking Industry 18.104.22.168 Base Tissue 22.214.171.124 Demineralized Bone Matrix Products 126.96.36.199 Machined Bone 3.2 Synthetic Bone Grafts 3.2.1 Products 3.3 Bone Graft Applications 3.3.1 Fracture Repair 3.3.2 Revision Total Joint Surgery 3.3.3 Tumors 3.3.4 Spine 3.4 Market Analysis 3.5 Competitive Analysis 3.5.1 Demineralized Bone Matrix 3.5.2 Machined Bone Allografts 3.5.3 Synthetic Bone Graft Substitutes Exhibit 3-1: Selected Categories of Bone Grafts Exhibit 3-2: Base Tissue Bone Allograft Applications in Orthopedic Surgery Exhibit 3-3: Base Tissue Bone Allograft Applications in Spine Surgery Exhibit 3-4: 2013, Description and Representative Pricing of Base Allografts Used in Spine Surgery Exhibit 3-5: 2013, Selected Demineralized Bone Matrix Products Exhibit 3-6: 2013, Selected Machined Bone Allografts Exhibit 3-7: Materials Used in Bone Graft Substitutes Exhibit 3-8: 2013, Selected Synthetic Bone Grafts Exhibit 3-9: Applications for Bone Grafts Exhibit 3-10: Bone Allografts and Synthetic Bone Graft Substitutes, Market Forecast, 2012-2017 Exhibit 3-11: 2012, Bone Allografts and Synthetic Bone Graft Substitutes Market, Share by Tissue Type Exhibit 3-12: 2012, Demineralized Bone Matrix Products Market, Share by Supplier Exhibit 3-13: 2012, Machined Bone Allografts Market, Share by Supplier Exhibit 3-14: 2012, Synthetic Bone Grafts Market, Share by Supplier 4. OSTEOBIOLOGICS 4.1 Bone Growth Factors 4.1.1 Bone Morphogenetic Proteins 188.8.131.52 Products 184.108.40.206.1 Infuse Bone Graft 220.127.116.11.2 Osteogenic Protein-1 18.104.22.168 Emerging Products 22.214.171.124 Clinical Trials 4.1.2 Fibroblast Growth Factors 4.1.3 Recombinant Platelet-Derived Growth Factor 126.96.36.199 Products 4.1.4 Autologous (Blood-Derived) Growth Factors 188.8.131.52 Products 4.2 Small Molecules 4.3 Stem Cell Therapy 4.3.1 Products 4.3.2 Emerging Products 4.4 Gene Therapy 4.4.1 Gene Therapy versus Growth Factors 4.4.2 Systemic Gene Therapy 4.4.3 Regional Gene Therapy 4.5 Other Osteobiologics 4.6 Market Analysis 4.6.1 Bone Morphogenetic Proteins 4.6.2 Other Osteobiologics 4.7 Competitive Analysis Exhibit 4-1: Selected Bone Morphogenetic Proteins Exhibit 4-2: Selected Recombinant Human Bone Morphogenetic Protein Products Exhibit 4-3: Selected Recombinant Human Bone Morphogenetic Proteins Under Development Exhibit 4-4: 2013, Selected Autologous Therapy/Platelet Concentrate Systems Exhibit 4-5: 2013, Selected Growth Factor and Small Molecule Therapies Under Development for Bone Healing and Spinal Fusion Applications Exhibit 4-6: 2013, Selected Stem Cell Products for Bone Healing and Enhancement of Spinal Fusion Exhibit 4-7: 2013, Selected Stem Cell Products Under Development for Orthopedic and Spinal Fusion Applications Exhibit 4-8: Comparison of Growth Factors with Gene Therapyfor Bone Repair Exhibit 4-9: Gene Therapy Delivery Methods for Bone Repair Exhibit 4-10: Recombinant Human Bone Morphogenetic Protein Products, Market Forecast, 2012-2017 Exhibit 4-11: Stem Cells and Other Osteobiologic Agents for Bone Healing and Enhancement of Spinal Fusion, Market Forecast, 2012-2017 Exhibit 4-12: 2012, Market Shares of Stem Cell Applications for Bone Healing and Spinal Fusion Exhibit 4-13: 2012, Stem Cell Products Market for Bone Healing and Spinal Fusion, Share by Supplier 5. COMPANY PROFILES 5.1 Arthrex, Inc. 5.2 Baxter International, Inc. 5.3 DiFusion Technologies 5.4 Johnson & Johnson 5.5 LifeNet Health, Inc. 5.6 Medtronic, Inc. 5.7 Musculoskeletal Transplant Foundation, Inc. 5.8 NuVasive, Inc. 5.9 Orthofix International NV 5.10 RTI Biologics, Inc. 5.11 Smith & Nephew PLC 5.12 Stryker Corporation APPENDIX: COMPANY LISTING