This dynamic new report from Medtech Insight includes analyses of products, competitors, and opportunities in the U.S. market for biomaterial products for bone healing/regeneration and spinal fusion indications. This market, as covered by the scope of this report, includes bioresorbable fixation devices (pins, screws, tacks, suture anchors, and meniscal repair devices); allografts and bone replacement materials (base tissue, demineralized bone matrix, machined bone allografts, and synthetic bone grafts), and osteobiologics (autologous therapy/platelet concentrate systems, gene therapy, platelet-derived growth factors, recombinant human bone morphogenetic proteins, small molecule therapies, and stem cells). During the forecast period covered by this report, the combined U.S. market for orthopedic biomaterials for bone repair and regeneration is projected to reach an estimated value of $3.5 billion in the year 2017.
This is the first of two reports covering the U.S. market for orthopedic biomaterials. Report #A322, "U.S. Markets for Orthopedic Biomaterials for Viscosupplementation and Cartilage, Ligament/Tendon, and Meniscal Repair and Regeneration" has also published.
EXECUTIVE SUMMARY i. Bioresorbable Fixation Devices ii. Bone Allograft and Synthetic Bone Graft Products iii. Osteobiologics iv. Combined Market Forecast v. Methodology Exhibit ES-1: Types of Bioresorbable Fixation Devices Exhibit ES-2: Bioresorbable Fixation Devices, Market Forecast, 2012-2017 Exhibit ES-3: Bone Allografts and Synthetic Bone Graft Substitutes, Market Forecast, 2012-2017 Exhibit ES-4: 2012, Bone Allografts and Synthetic Bone Graft Substitutes Market, Share by Tissue Type Exhibit ES-5: Recombinant Human Bone Morphogenetic Protein Products, Market Forecast, 2012-2017 Exhibit ES-6: Osteobiologics, Market Forecast, 2012-2017 Exhibit ES-7: 2012, Market Shares of Stem Cell Applications for Bone Healing and Spinal Fusion Exhibit ES-8: Orthopedic Biomaterials for Bone Repair and Regeneration, Combined Market Forecast, 2012-2017 1. MUSCULOSKELETAL SYSTEM OVERVIEW 1.1 Bone Structure and Function 1.1.1 Cellular Framework 22.214.171.124 Osteoblasts 126.96.36.199 Osteocytes 188.8.131.52 Osteoclasts 184.108.40.206 Osteogenesis 1.1.2 Bone Tissue 220.127.116.11 Cancellous and Cortical Bone Tissue 18.104.22.168 Bone Marrow 1.1.3 Bone Anatomy 22.214.171.124 Diaphysis and Epiphysis 126.96.36.199 Endosteum 188.8.131.52 Periosteum 1.1.4 Joint Components 184.108.40.206 Cartilage 220.127.116.11.1 Elastic Cartilage 18.104.22.168.2 Fibrocartilage 22.214.171.124.3 Hyaline Cartilage 126.96.36.199 Bursae 188.8.131.52 Joint Cavity 184.108.40.206 Menisci 220.127.116.11 Synovial Membrane and Fluid 18.104.22.168 Ligaments and Tendons 22.214.171.124 Muscles 1.1.5 Joint Structures 126.96.36.199 Ankle 188.8.131.52 Digits 184.108.40.206 Elbow 220.127.116.11 Hip 18.104.22.168 Knee 22.214.171.124 Shoulder 126.96.36.199 Wrist 1.1.6 Bone Formation and Remodeling 188.8.131.52 In the Fetus 184.108.40.206 In Childhood 220.127.116.11 In Adulthood 18.104.22.168 In Old Age 22.214.171.124 Mechanical Stress and Wolff's Law 1.1.7 Factors Affecting Bone Physiology 126.96.36.199 Age 188.8.131.52 Gender 184.108.40.206 Genetic Disposition 220.127.116.11 Hormonal Activity 18.104.22.168 Physical Activity 22.214.171.124 Cigarette Smoking 126.96.36.199 Alcohol and Caffeine Intake 188.8.131.52 Nutritional Deficiencies 1.2 Joint Structure and Function 1.2.1 Types of Joints 184.108.40.206 Synarthroses 220.127.116.11 Amphiarthroses 18.104.22.168 Diarthroses 22.214.171.124.1 Ball-and-Socket 126.96.36.199.2 Condyloid 188.8.131.52.3 Hinge 184.108.40.206.4 Gliding 220.127.116.11.5 Pivot 1.2.2 Arthritis 18.104.22.168 Osteoarthritis 22.214.171.124 Rheumatoid Arthritis 1.3 Management of Joint Disorders 1.3.1 Joint Replacement 126.96.36.199 Dislocation 188.8.131.52 Ligament and Tendon Injuries 184.108.40.206 Meniscal Injuries Exhibit 1-1: Illustration of Bone Tissue Exhibit 1-2: Types of Cartilage Exhibit 1-3: Stages of Bone Remodeling 2. BIORESORBABLE FIXATION DEVICES 2.1 Materials 2.2 Products 2.2.1 Bioresorbable Pins 2.2.2 Bioresorbable Screws, Nails, and Tacks 2.2.3 Bioresorbable Interference Screws 2.2.4 Bioresorbable Suture Anchors 2.2.5 Bioresorbable Meniscal Repair Devices 2.3 Market Analysis 2.3.1 Potential Market for Bioresorbable Fixation Devices 220.127.116.11 Meniscal Repair 18.104.22.168 Cruciate Ligament Fixation 22.214.171.124 Shoulder Reconstruction 126.96.36.199 Small Joint/Bone Fragment Fixation 2.4 Competitive Analysis Exhibit 2-1: Advantages of Bioresorbable Fixation Devices Exhibit 2-2: Factors Affecting the Properties of Bioresorbable Polymers Exhibit 2-3: Types of Bioresorbable Fixation Devices Exhibit 2-4: 2013, Selected Bioresorbable Pins Exhibit 2-5: 2013, Selected Bioresorbable Nails, Screws, and Tacks Exhibit 2-6: 2013, Selected Bioresorbable Interference Screws Exhibit 2-7: 2013, Selected Bioresorbable Suture Anchors Exhibit 2-8: 2013, Selected Bioresorbable Meniscal Repair Devices Exhibit 2-9: 2012, Bioresorbable Fixation Devices Market, By Procedure Type Exhibit 2-10: Bioresorbable Fixation Devices, Market Forecast, 2012-2017 Exhibit 2-11: 2012, Bioresorbable Fixation Devices Market, Share by Supplier 3. BONE ALLOGRAFT AND SYNTHETIC BONE GRAFT PRODUCTS 3.1 Bone Graft Materials 3.1.1 Autograft 3.1.2 Allograft 188.8.131.52 Regulations Governing Allograft Providers 184.108.40.206.1 National Organ Transplant Act 220.127.116.11.2 United States Food and Drug Administration Requirements 18.104.22.168 Donor Screening 22.214.171.124 Recovering Tissue 126.96.36.199 Processing Tissue 188.8.131.52 Tissue Banking Industry 184.108.40.206 Base Tissue 220.127.116.11 Demineralized Bone Matrix Products 18.104.22.168 Machined Bone 3.2 Synthetic Bone Grafts 3.2.1 Products 3.3 Bone Graft Applications 3.3.1 Fracture Repair 3.3.2 Revision Total Joint Surgery 3.3.3 Tumors 3.3.4 Spine 3.4 Market Analysis 3.5 Competitive Analysis 3.5.1 Demineralized Bone Matrix 3.5.2 Machined Bone Allografts 3.5.3 Synthetic Bone Graft Substitutes Exhibit 3-1: Selected Categories of Bone Grafts Exhibit 3-2: Base Tissue Bone Allograft Applications in Orthopedic Surgery Exhibit 3-3: Base Tissue Bone Allograft Applications in Spine Surgery Exhibit 3-4: 2013, Description and Representative Pricing of Base Allografts Used in Spine Surgery Exhibit 3-5: 2013, Selected Demineralized Bone Matrix Products Exhibit 3-6: 2013, Selected Machined Bone Allografts Exhibit 3-7: Materials Used in Bone Graft Substitutes Exhibit 3-8: 2013, Selected Synthetic Bone Grafts Exhibit 3-9: Applications for Bone Grafts Exhibit 3-10: Bone Allografts and Synthetic Bone Graft Substitutes, Market Forecast, 2012-2017 Exhibit 3-11: 2012, Bone Allografts and Synthetic Bone Graft Substitutes Market, Share by Tissue Type Exhibit 3-12: 2012, Demineralized Bone Matrix Products Market, Share by Supplier Exhibit 3-13: 2012, Machined Bone Allografts Market, Share by Supplier Exhibit 3-14: 2012, Synthetic Bone Grafts Market, Share by Supplier 4. OSTEOBIOLOGICS 4.1 Bone Growth Factors 4.1.1 Bone Morphogenetic Proteins 22.214.171.124 Products 126.96.36.199.1 Infuse Bone Graft 188.8.131.52.2 Osteogenic Protein-1 184.108.40.206 Emerging Products 220.127.116.11 Clinical Trials 4.1.2 Fibroblast Growth Factors 4.1.3 Recombinant Platelet-Derived Growth Factor 18.104.22.168 Products 4.1.4 Autologous (Blood-Derived) Growth Factors 22.214.171.124 Products 4.2 Small Molecules 4.3 Stem Cell Therapy 4.3.1 Products 4.3.2 Emerging Products 4.4 Gene Therapy 4.4.1 Gene Therapy versus Growth Factors 4.4.2 Systemic Gene Therapy 4.4.3 Regional Gene Therapy 4.5 Other Osteobiologics 4.6 Market Analysis 4.6.1 Bone Morphogenetic Proteins 4.6.2 Other Osteobiologics 4.7 Competitive Analysis Exhibit 4-1: Selected Bone Morphogenetic Proteins Exhibit 4-2: Selected Recombinant Human Bone Morphogenetic Protein Products Exhibit 4-3: Selected Recombinant Human Bone Morphogenetic Proteins Under Development Exhibit 4-4: 2013, Selected Autologous Therapy/Platelet Concentrate Systems Exhibit 4-5: 2013, Selected Growth Factor and Small Molecule Therapies Under Development for Bone Healing and Spinal Fusion Applications Exhibit 4-6: 2013, Selected Stem Cell Products for Bone Healing and Enhancement of Spinal Fusion Exhibit 4-7: 2013, Selected Stem Cell Products Under Development for Orthopedic and Spinal Fusion Applications Exhibit 4-8: Comparison of Growth Factors with Gene Therapyfor Bone Repair Exhibit 4-9: Gene Therapy Delivery Methods for Bone Repair Exhibit 4-10: Recombinant Human Bone Morphogenetic Protein Products, Market Forecast, 2012-2017 Exhibit 4-11: Stem Cells and Other Osteobiologic Agents for Bone Healing and Enhancement of Spinal Fusion, Market Forecast, 2012-2017 Exhibit 4-12: 2012, Market Shares of Stem Cell Applications for Bone Healing and Spinal Fusion Exhibit 4-13: 2012, Stem Cell Products Market for Bone Healing and Spinal Fusion, Share by Supplier 5. COMPANY PROFILES 5.1 Arthrex, Inc. 5.2 Baxter International, Inc. 5.3 DiFusion Technologies 5.4 Johnson & Johnson 5.5 LifeNet Health, Inc. 5.6 Medtronic, Inc. 5.7 Musculoskeletal Transplant Foundation, Inc. 5.8 NuVasive, Inc. 5.9 Orthofix International NV 5.10 RTI Biologics, Inc. 5.11 Smith & Nephew PLC 5.12 Stryker Corporation APPENDIX: COMPANY LISTING